Based on the current situation of cadmium(Cd)-arsenic(As) combined pollution in paddy soils in southern China, this study investigates, under hydroponic conditions, whether the application of different silicon(Si) fertilizers addition methods(spraying to foliage(FSi), solution culture addition(Si) and both(FSi+Si) )or different Si content(20 mg·kg-1(Si(20) )and 40 mg·kg-1(Si(40)) can simulaneously reduce Cd and As concentration in rice grain. Results indicate that three addition methods of Si application can significantly reduce the Cd and As concentration in rice grain, the effect of Si(40) on Cd and As concentration in rice grain was more applicable than SiSi) significantly decreased Cd and inorganic As accumulation in brown rice compared to the control(p<0.05); treatments="" of="" si(20)</sub> and Si(40) can sharply reduced Cd and inorganic As concentration in rice(50% or more) compared to the control, but there was still risk of exceeding the standard limit for Food Safe of People’s Republic of China(0.2 mg·kg-1 Cd and inorganic As ); In addition, FSi+Si and FSi+Si(40) have the best effect to decreased Cd and inorganic As concentration in edible grains. The results of this investigation demonstrated the potential effects of FSi+Si in reducing Cd and As concentrations in rice grain.0.05);>